Szymanski L, Kedesdy J, Sulkes S, Cutler A, Stevens-Our P
Children's Hospital, Boston, MA.
Res Dev Disabil. 1987;8(2):179-90. doi: 10.1016/0891-4222(87)90002-3.
It has been suggested that the parenteral opiate antagonist, naloxone, might ameliorate self-injurious behavior. However, clinical studies have had conflicting results. We have evaluated whether a potent oral opiate antagonist, naltrexone, is effective in the treatment of this condition. The study was conducted on two young, profoundly mentally retarded adults, who exhibited intractable self-injurious behavior. A double-blind, placebo-controlled, within-subject-withdrawal design was utilized. One subject was studied for 12 weeks and the other one for 18 weeks. No measurable effects on the self-injurious behavior were observed.
有人提出，肠胃外阿片类拮抗剂纳洛酮可能会改善自伤行为。然而，临床研究结果相互矛盾。我们评估了一种强效口服阿片类拮抗剂纳曲酮治疗这种病症是否有效。该研究针对两名患有严重智力障碍的年轻成年人进行，他们表现出难以控制的自伤行为。采用了双盲、安慰剂对照、受试者内撤药设计。一名受试者接受了12周的研究，另一名受试者接受了18周的研究。未观察到对自伤行为有可测量的影响。
