环磷酸腺苷可能不参与酿酒酵母中的分解代谢物阻遏：来自无法合成它的突变体的证据。
Cyclic AMP may not be involved in catabolite repression in Saccharomyces cerevisiae: evidence from mutants unable to synthesize it.
作者信息
Matsumoto K, Uno I, Ishikawa T, Oshima Y
出版信息
J Bacteriol. 1983 Nov;156(2):898-900. doi: 10.1128/jb.156.2.898-900.1983.
Abstract
Yeast cells with a nonsense adenylate cyclase mutation, cyr1-3, required cyclic AMP for growth. This phenotype was suppressed by the byc1 mutation; however, cyr1-3 bcy1 cells produced no detectable level of adenylate cyclase or cyclic AMP. On induction, the bcy1 and cyr1-3 bcy1 mutant cells produced the same levels of galactokinase and alpha-D-glucosidase as did the wild-type cells and fourfold-higher levels of invertase. Since galactokinase synthesis was severely repressed by glucose in the constitutive GAL81 mutants, irrespective of the cyr1-3 bcy1 genotype, cyclic AMP may not be involved in catabolite repression.
摘要
带有无义腺苷酸环化酶突变（cyr1-3）的酵母细胞生长需要环磷酸腺苷（cAMP）。这种表型被byc1突变所抑制；然而，cyr1-3 bcy1细胞未检测到可检测水平的腺苷酸环化酶或环磷酸腺苷。诱导后，bcy1和cyr1-3 bcy1突变细胞产生的半乳糖激酶和α-D-葡萄糖苷酶水平与野生型细胞相同，蔗糖酶水平则高出四倍。由于在组成型GAL81突变体中，无论cyr1-3 bcy1基因型如何，半乳糖激酶的合成都会被葡萄糖严重抑制，因此环磷酸腺苷可能不参与分解代谢物阻遏。
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1
Function of positive regulatory gene gal4 in the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae: evidence that the GAL81 region codes for part of the gal4 protein.正调控基因gal4在酿酒酵母半乳糖途径酶合成中的作用：GAL81区域编码gal4蛋白一部分的证据。
J Bacteriol. 1980 Feb;141(2):508-27. doi: 10.1128/jb.141.2.508-527.1980.
2
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3
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4
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5
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Science. 1970 Jul 24;169(3943):339-44. doi: 10.1126/science.169.3943.339.
6
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Biochem Biophys Res Commun. 1969 Sep 24;37(1):151-7. doi: 10.1016/0006-291x(69)90893-6.
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