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伊曲康唑与酮康唑治疗实验性念珠菌性阴道炎的比较。

Comparison of itraconazole and ketoconazole in the treatment of experimental candidal vaginitis.

作者信息

Sobel J D, Muller G

出版信息

Antimicrob Agents Chemother. 1984 Aug;26(2):266-7. doi: 10.1128/AAC.26.2.266.

DOI:10.1128/AAC.26.2.266
PMID:6091538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284134/
Abstract

Comparison of itraconazole (R51,211) and ketoconazole in the treatment of experimental candidal vaginitis in rats on schedules of 3 and 5 days revealed significantly superior results with itraconazole at all dosages (1.0 to 7.5 mg/kg) studied, but was particularly evident at 1.0 and 2.5 mg/kg. A single 25-mg/kg dose of itraconazole was as effective as 5 daily 5-mg/kg doses of itraconazole.

摘要

在大鼠实验性念珠菌性阴道炎治疗中，按3天和5天疗程比较伊曲康唑（R51,211）和酮康唑，结果显示，在所研究的所有剂量（1.0至7.5毫克/千克）下，伊曲康唑的疗效显著优于酮康唑，在1.0和2.5毫克/千克剂量时尤为明显。伊曲康唑单次25毫克/千克剂量与每日5毫克/千克、连用5天的疗效相同。

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本文引用的文献

1
Comparison of ketoconazole, Bay N7133, and Bay L9139 in the treatment of experimental vaginal candidiasis.酮康唑、Bay N7133和Bay L9139治疗实验性阴道念珠菌病的比较。
Antimicrob Agents Chemother. 1983 Sep;24(3):434-6. doi: 10.1128/AAC.24.3.434.
2
Treatment of vaginal candidiasis with ketoconazole, a new, orally active, antimycotic.用酮康唑（一种新型口服活性抗真菌药）治疗阴道念珠菌病。
Eur J Obstet Gynecol Reprod Biol. 1979 Aug;9(4):253-9. doi: 10.1016/0028-2243(79)90065-0.
3
Cure and relapse with antifungal therapy.抗真菌治疗的治愈与复发
Proc R Soc Med. 1977;70 Suppl 4(Suppl 4):24-32. doi: 10.1177/00359157770700S407.