伊曲康唑与酮康唑治疗实验性念珠菌性阴道炎的比较。
Comparison of itraconazole and ketoconazole in the treatment of experimental candidal vaginitis.
作者信息
Sobel J D, Muller G
出版信息
Antimicrob Agents Chemother. 1984 Aug;26(2):266-7. doi: 10.1128/AAC.26.2.266.
Abstract
Comparison of itraconazole (R51,211) and ketoconazole in the treatment of experimental candidal vaginitis in rats on schedules of 3 and 5 days revealed significantly superior results with itraconazole at all dosages (1.0 to 7.5 mg/kg) studied, but was particularly evident at 1.0 and 2.5 mg/kg. A single 25-mg/kg dose of itraconazole was as effective as 5 daily 5-mg/kg doses of itraconazole.
摘要
在大鼠实验性念珠菌性阴道炎治疗中，按3天和5天疗程比较伊曲康唑（R51,211）和酮康唑，结果显示，在所研究的所有剂量（1.0至7.5毫克/千克）下，伊曲康唑的疗效显著优于酮康唑，在1.0和2.5毫克/千克剂量时尤为明显。伊曲康唑单次25毫克/千克剂量与每日5毫克/千克、连用5天的疗效相同。
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