Callaghan D J, Conner B R, Strauss M
Arch Otolaryngol. 1983 Dec;109(12):781-4. doi: 10.1001/archotol.1983.00800260003001.
Pretreatment serum samples from 39 white American patients with epidermoid cancer of various sites of the head and neck, including the nasopharynx, were studied for both IgA and IgG antibodies to the Epstein-Barr virus (EBV)-specific antigens. Of the various serological assays, IgG anti-viral capsid antigen (VCA) was least specific and was present frequently at high titers in both the groups with nasopharyngeal carcinoma (NPC) and groups with other cancers (OC). The geometric mean titer (GMT) of IgA anti-VCA was significantly elevated in patients with NPC compared with the groups with OC. The incidence of this virologic parameter was high in the laryngeal and stage III and IV oral cavity groups of epidermoid cancer, and the GMTs were significantly greater than the control group. Finally, the GMTs of all the antibodies to the EBV-associated antigens were significantly elevated in patients with NPC who had regional metastases compared with those who had local disease with cranial nerve involvement.
对39名患有头颈部不同部位（包括鼻咽部）表皮样癌的美国白人患者的预处理血清样本进行了研究，以检测针对爱泼斯坦-巴尔病毒（EBV）特异性抗原的IgA和IgG抗体。在各种血清学检测中，IgG抗病毒衣壳抗原（VCA）特异性最低，在鼻咽癌（NPC）组和其他癌症（OC）组中均经常出现高滴度。与OC组相比，NPC患者中IgA抗VCA的几何平均滴度（GMT）显著升高。该病毒学参数在喉癌以及表皮样癌的III期和IV期口腔癌组中的发生率较高，且GMT显著高于对照组。最后，与患有局部疾病且伴有颅神经受累的NPC患者相比，有区域转移的NPC患者中所有针对EBV相关抗原的抗体的GMT均显著升高。
