Backman C, Olofsson B O
Acta Med Scand. 1983;214(4):273-8. doi: 10.1111/j.0954-6820.1983.tb10634.x.
Twenty-two patients with the Swedish variant of familial amyloidosis with polyneuropathy were studied by M-mode and two-dimensional echocardiography. These patients had few symptoms consistent with cardiac disease but, nevertheless, echocardiograms of only two of them, both with a short history of the disease, were considered normal in all aspects. The most common abnormality was increased thickness of the interventricular septum found in 20 (91%) of the patients. This septal hypertrophy was asymmetric in 12 (55%) of them. Two-dimensional echocardiography revealed a characteristic hyperrefractile appearance of the myocardium in 15 (68%) of the patients. Thus, echocardiography showed a characteristic pattern in these patients. This study also indicates that cardiac amyloidosis can be diagnosed in the preclinical, asymptomatic state by M-mode and two-dimensional echocardiography.
对22例患有伴有多神经病的瑞典型家族性淀粉样变性患者进行了M型和二维超声心动图研究。这些患者几乎没有与心脏病相符的症状，然而，其中只有两名病程较短的患者的超声心动图在各方面均被认为正常。最常见的异常是20例（91%）患者的室间隔厚度增加。其中12例（55%）的室间隔肥厚不对称。二维超声心动图显示15例（68%）患者的心肌呈现特征性的高回声表现。因此，超声心动图在这些患者中显示出一种特征性模式。本研究还表明，通过M型和二维超声心动图可在临床前期无症状状态下诊断心脏淀粉样变性。
