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整合型牛白血病前病毒DNA长末端重复序列以及相邻病毒和宿主序列的核苷酸序列分析。

Nucleotide sequence analysis of the long terminal repeat of integrated bovine leukemia provirus DNA and of adjacent viral and host sequences.

作者信息

Couez D, Deschamps J, Kettmann R, Stephens R M, Gilden R V, Burny A

出版信息

J Virol. 1984 Feb;49(2):615-20. doi: 10.1128/JVI.49.2.615-620.1984.

DOI:10.1128/JVI.49.2.615-620.1984
PMID:6319764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255509/
Abstract

The nucleotide sequence of the 3' long terminal repeat and adjacent viral and host sequences was determined for a bovine leukemia provirus cloned from a bovine tumor. The long terminal repeat was found to comprise 535 nucleotides and to harbor at both ends an imperfect inverted repeat of 7 bases. Promoter-like sequences (Hogness box and CAT box), an mRNA capping site, and a core enhancer-related sequence were tentatively located. No kinship was detected between this bovine leukemia proviral fragment and other retroviral long terminal repeats, including that of human T-cell leukemia virus.

摘要

从牛肿瘤中克隆出的牛白血病前病毒，测定了其3' 长末端重复序列以及相邻的病毒和宿主序列的核苷酸序列。发现长末端重复序列由535个核苷酸组成，两端含有一个7个碱基的不完全反向重复序列。初步定位了启动子样序列（霍格尼斯盒和CAT盒）、一个mRNA加帽位点以及一个与核心增强子相关的序列。在这个牛白血病前病毒片段与其他逆转录病毒长末端重复序列之间未检测到亲缘关系，包括人类T细胞白血病病毒的长末端重复序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1562/255509/03b87da7c80f/jvirol00137-0324-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1562/255509/03b87da7c80f/jvirol00137-0324-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1562/255509/03b87da7c80f/jvirol00137-0324-a.jpg

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