禽成髓细胞瘤病毒长末端重复序列及相邻宿主序列的核苷酸序列分析。
Nucleotide sequence analysis of the long terminal repeat of avian myeloblastosis virus and adjacent host sequences.
作者信息
Rushlow K E, Lautenberger J A, Reddy E P, Souza L M, Baluda M A, Chirikjian J G, Papas T S
出版信息
J Virol. 1982 Jun;42(3):840-6. doi: 10.1128/JVI.42.3.840-846.1982.
Abstract
The nucleotide sequence of the integrated avian myeloblastosis virus long terminal repeat has been determined. The sequence is 385 base pairs long and is present at both ends of the viral DNA. The cell-virus junctions at each end consist of a 6-base-pair direct repeat of cell DNA next to the inverted repeat of viral DNA. The long terminal repeat also contains promoter-like sequences, an mRNA capping site, and polyadenylation signals. Several features of this long terminal repeat suggest a structural and functional similarity with sequences of transposable and other genetic elements. Comparison of these sequences with long terminal repeats of other avian retroviruses indicates that there is a great variation in the 3' unique sequence (U3), whereas the 5' specific sequences (U5) and the R region are highly conserved.
摘要
已确定整合的禽成髓细胞瘤病毒长末端重复序列的核苷酸序列。该序列长385个碱基对，存在于病毒DNA的两端。两端的细胞 - 病毒连接处由病毒DNA反向重复序列旁的6个碱基对的细胞DNA直接重复序列组成。长末端重复序列还包含启动子样序列、mRNA加帽位点和聚腺苷酸化信号。该长末端重复序列的几个特征表明它与转座子和其他遗传元件的序列在结构和功能上具有相似性。将这些序列与其他禽逆转录病毒的长末端重复序列进行比较表明，3' 独特序列（U3）存在很大差异，而5' 特异性序列（U5）和R区域高度保守。
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