Wilcox J, Sage M R, Evill C A
AJNR Am J Neuroradiol. 1984 Jan-Feb;5(1):41-3.
Increasingly large doses of contrast medium have been advocated for enhanced computed tomography. It is assumed that such large intravenous doses, which increase the osmolality of the blood, do not affect the blood-brain barrier in the same way as intracarotid injections of the same solutions. Using a qualitative marker, Evans blue dye, and a quantitative marker, 99mTc-pertechnetate, a study was performed in rabbits to assess the effect of intravenous sodium iothalamate (Conray-420) at a dose of 8 ml/kg on the integrity of the blood-brain barrier. No qualitative or quantitative evidence of disruption of the blood-brain barrier was demonstrated. Since histologic examination was not done, morphologic changes cannot be excluded.
越来越大剂量的造影剂被推荐用于增强计算机断层扫描。据推测，如此大剂量的静脉注射会增加血液的渗透压，但与相同溶液的颈动脉注射相比，对血脑屏障的影响方式不同。使用定性标记物伊文思蓝染料和定量标记物高锝酸盐99mTc，在兔子身上进行了一项研究，以评估静脉注射8ml/kg剂量的碘他拉酸钠（康瑞-420）对血脑屏障完整性的影响。未发现血脑屏障破坏的定性或定量证据。由于未进行组织学检查，不能排除形态学变化。
