Wilcox J, Sage M R
Neuroradiology. 1984;26(6):511-3. doi: 10.1007/BF00342690.
A canine model was used to investigate the effects of intracarotid methylglucamine iothalamate (280 mgI/ml) at different viscosities on the normal blood-brain barrier. To alter viscosity, without changing physiochemical parameters, injections were made at either 23 degrees C or 37 degrees C. The degree of blood-brain barrier damage was assessed using Evans' Blue dye as a visual marker and by contrast enhancement measured by a computed tomographic (CT) scanner. It was found that methylglucamine iothalamate caused more blood-brain barrier damage at 23 degrees C than at 37 degrees C (p less than 0.1). Control studies at each temperature using intracarotid injections of physiological saline showed no temperature effect (p greater than 0.1). The implications of these findings are discussed.
使用犬类模型研究不同粘度的颈动脉内注射碘他拉葡甲胺（280 mgI/ml）对正常血脑屏障的影响。为了在不改变理化参数的情况下改变粘度，分别在23℃或37℃下进行注射。使用伊文思蓝染料作为视觉标记，并通过计算机断层扫描（CT）扫描仪测量的对比增强来评估血脑屏障损伤程度。结果发现，在23℃时碘他拉葡甲胺对血脑屏障的损伤比在37℃时更严重（p<0.1）。在每个温度下使用颈动脉内注射生理盐水的对照研究显示无温度效应（p>0.1）。讨论了这些发现的意义。
