Wahren B, Einhorn L, Gadler H
Arch Virol. 1984;79(1-2):55-65. doi: 10.1007/BF01314303.
Adsorption of cytomegalovirus (CMV) to human fibroblasts was not inhibited by preincubation with other herpes viruses (HSV-1, HSV-2, VZV). Transport of virus to the nucleus was studied using virus labelled with 3H-thymidine. Radioactivity was found in the nucleus 20 minutes after virus had been added to the cells. In order to assess the expression of the virus genome, synthesis of early (EA) and late (LA) antigens was studied. Assayed on permissive human lung fibroblasts, a plaque purified virus contained more EA inducing than both EA and LA inducing viral units. Since this was a consistent finding with virions of all densities, it seems to be an effect of viral dose rather than of virion density. Alternatively, LA-defectiveness is a virion property which does not vary with virion density.
巨细胞病毒（CMV）对人成纤维细胞的吸附不会因与其他疱疹病毒（单纯疱疹病毒1型、单纯疱疹病毒2型、水痘带状疱疹病毒）预孵育而受到抑制。使用用³H-胸腺嘧啶核苷标记的病毒研究病毒向细胞核的转运。在将病毒添加到细胞后20分钟，在细胞核中发现了放射性。为了评估病毒基因组的表达，研究了早期（EA）和晚期（LA）抗原的合成。在用允许性人肺成纤维细胞进行检测时，一种空斑纯化病毒所含诱导EA的能力比诱导EA和LA的病毒单位都要强。由于这是所有密度病毒粒子的一致发现，这似乎是病毒剂量的效应而非病毒粒子密度的效应。或者，LA缺陷是一种不随病毒粒子密度变化的病毒粒子特性。
