泛醌在人中性粒细胞中的亚细胞定位。
The subcellular localization of ubiquinone in human neutrophils.
作者信息
Cross A R, Jones O T, Garcia R, Segal A W
出版信息
Biochem J. 1983 Dec 15;216(3):765-8. doi: 10.1042/bj2160765.
Abstract
Ubiquinone-10 has recently been proposed as a component of the microbicidal oxidase system of neutrophil leukocytes [Crawford & Schneider (1982) J. Biol. Chem. 257, 6662-6668]. We have determined the subcellular localization of ubiquinone and could detect it only in the mitochondrial fractions. It was not enriched in phagolysosomes which were enriched in O2-. generating activity and cytochrome b-245. It is proposed that ubiquinone is unlikely to play a direct role in the electron transport chain located in the plasma membrane which functions to produce microbicidal oxygen radicals.
摘要
最近，泛醌 -10被认为是中性粒细胞杀菌氧化酶系统的一个组成部分[克劳福德和施奈德（1982年），《生物化学杂志》257卷，6662 - 6668页]。我们已经确定了泛醌的亚细胞定位，并且仅在线粒体组分中检测到它。它在富含超氧阴离子生成活性和细胞色素b - 245的吞噬溶酶体中并未富集。有人提出，泛醌不太可能在位于质膜上用于产生杀菌性氧自由基的电子传递链中发挥直接作用。
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Evidence that a quinone may be required for the production of superoxide and hydrogen peroxide in neutrophils.有证据表明，醌可能是中性粒细胞产生超氧化物和过氧化氢所必需的。
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