Kojo H, Shigi Y, Nishida M
J Antibiot (Tokyo). 1980 Mar;33(3):317-21. doi: 10.7164/antibiotics.33.317.
The ability of ceftizoxime to penetrate the outer membrane was compared with those of five other new cephalosporins: cefotiam, cefuroxime, cefotaxime, cefmetazole and cefoxitin, using a clinical isolate of Enterobacter cloacae as a test strain. Estimation of permeability was performed by a method utilizing the inhibitory activities of the cephalosporins against beta-lactamase located in the periplasm. Of the cephalosporins tested, both ceftizoxime and cefmetazole gave remarkably high concentrations in the periplasm, several times higher than those of cefotaxime and cefoxitin and ten or more times higher than those of cefuroxime and cefotiam. The approximate permeability coefficient of ceftizoxime was also several times higher than those of cefotiam and cefmetazole and over ten times higher than those of cefoxitin, cefuroxime and cefotaxime.
以阴沟肠杆菌的临床分离株作为测试菌株，比较了头孢唑肟与其他五种新型头孢菌素（头孢替安、头孢呋辛、头孢噻肟、头孢美唑和头孢西丁）穿透外膜的能力。通过利用头孢菌素对位于周质中的β-内酰胺酶的抑制活性的方法来进行通透性评估。在所测试的头孢菌素中，头孢唑肟和头孢美唑在周质中均产生了非常高的浓度，比头孢噻肟和头孢西丁高几倍，比头孢呋辛和头孢替安高十多倍。头孢唑肟的近似通透系数也比头孢替安和头孢美唑高几倍，比头孢西丁、头孢呋辛和头孢噻肟高十多倍。
