Schüpbach J, Sarngadharan M G, Gallo R C
Science. 1984 May 11;224(4649):607-10. doi: 10.1126/science.6324349.
Cross-reactive antigens of molecular size of 61,000 to 68,000 daltons are found on the surface of human cells infected by human T-cell leukemia-lymphoma virus (HTLV). They are recognized by antibodies from patients with adult T-cell leukemias and lymphomas, from healthy carriers of HTLV, and from patients with the acquired immunodeficiency syndrome (AIDS). The latter finding has been one of the major reasons for suggesting an association of HTLV with AIDS. However, whether these antigens are of cellular or viral origin has not been clear. These antigens have now been shown to be associated with the presence of viral proteins in the cells, and a cross-reactive glycoprotein of molecular size of 46,000 daltons has been found to be a consistent structural part of viruses purified from several HTLV-producer cell lines. The findings thus suggest a viral (HTLV) origin of these antigens.
在感染人类T细胞白血病-淋巴瘤病毒（HTLV）的人类细胞表面发现了分子大小为61,000至68,000道尔顿的交叉反应性抗原。它们可被成人T细胞白血病和淋巴瘤患者、HTLV健康携带者以及获得性免疫缺陷综合征（AIDS）患者的抗体识别。后一项发现是提示HTLV与AIDS有关联的主要原因之一。然而，这些抗原是细胞源性还是病毒源性尚不清楚。现已证明这些抗原与细胞中病毒蛋白的存在有关，并且已发现一种分子大小为46,000道尔顿的交叉反应性糖蛋白是从几种HTLV产生细胞系中纯化出的病毒的一致结构组成部分。因此，这些发现提示这些抗原起源于病毒（HTLV）。
