表达人嗜T淋巴细胞病毒I型包膜基因的重组痘苗病毒对人嗜T淋巴细胞病毒I型感染的影响
Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection.
作者信息
Shida H, Tochikura T, Sato T, Konno T, Hirayoshi K, Seki M, Ito Y, Hatanaka M, Hinuma Y, Sugimoto M
机构信息
Institute for Virus Research, Kyoto University, Japan.
出版信息
EMBO J. 1987 Nov;6(11):3379-84. doi: 10.1002/j.1460-2075.1987.tb02660.x.
The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection.
人类嗜T淋巴细胞病毒I型（HTLV-I）在病因上与成人T细胞白血病（ATL）相关。为研发针对ATL的疫苗，我们构建了重组痘苗病毒，其在痘苗病毒血凝素（HA）基因（一个可插入外源基因的新位点）中包含HTLV-I的包膜基因。单次接种该重组病毒可诱导兔体内产生针对HTLV-I env蛋白的抗体，并对HTLV-I感染具有保护作用。
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