Zouali M, Drouhet E, Eyquem A
Mycopathologia. 1984 Feb 15;84(2-3):87-93. doi: 10.1007/BF00436518.
Six patients with chronic mucocutaneous candidiasis (CMCC) were investigated for the presence of auto-antibodies during the course of the infection. Sera were tested for antibodies to native DNA (dsDNA) and denatured DNA (ssDNA), mitochondrial and microsomal antigens, smooth muscle, gastric parietal cells, basal membrane and skin intercellular substance, parathyroid glands, thyroglobulin and microsomal antigen, immunoglobulins and for anti-nuclear antibodies. Auto-antibodies were detected by radioimmunoassay, immunofluorescence, hemagglutination and other routine methods. Tests were performed at the end of the observation period, with the same batches of antigens and at the same time for all patients. Organ-specific antibodies (gastric parietal cells and intercellular substance) were found at low titers in five patients. Anti-smooth muscle antibodies were increased in two patients. In four patients antibodies to ssDNA were elevated. Moreover high titers of anti-ssDNA antibodies correlated well with disease activity after treatment with Ketoconazole in four tested patients. The possibility that C. albicans infection may induce auto-antibodies should be considered in assessing their disease activity significance in other chronic infected patients. The mechanisms of appearance of auto-antibodies and their immunopathological significance in CMCC are discussed.
对6例慢性黏膜皮肤念珠菌病（CMCC）患者在感染过程中是否存在自身抗体进行了调查。检测血清中针对天然DNA（dsDNA）和变性DNA（ssDNA）、线粒体和微粒体抗原、平滑肌、胃壁细胞、基底膜和皮肤细胞间物质、甲状旁腺、甲状腺球蛋白和微粒体抗原、免疫球蛋白以及抗核抗体的抗体。通过放射免疫测定、免疫荧光、血凝和其他常规方法检测自身抗体。在观察期结束时，对所有患者使用相同批次的抗原并在同一时间进行检测。在5例患者中发现了低滴度的器官特异性抗体（胃壁细胞和细胞间物质）。2例患者的抗平滑肌抗体升高。4例患者的ssDNA抗体升高。此外，在4例接受检测的患者中，高滴度的抗ssDNA抗体与酮康唑治疗后的疾病活动度密切相关。在评估其他慢性感染患者自身抗体的疾病活动度意义时，应考虑白色念珠菌感染可能诱导自身抗体的可能性。本文讨论了CMCC中自身抗体出现的机制及其免疫病理学意义。
