Ackermann M, Wyler R
Vet Microbiol. 1984 Feb;9(1):53-63. doi: 10.1016/0378-1135(84)90078-6.
Two calves were inoculated intravaginally with a strain of bovid herpesvirus type 1 (BHV-1, IBR/IPV) isolated from a cow with infectious pustular vulvovaginitis (IPV). The animals were killed during a latent stage of infection as characterized by seroconversion, absence of virus shedding and recrudescence of virus shedding after dexamethasone treatment. IPV-virus DNA was detected in 9 out of 20 sacral ganglia of the 2 calves. Of the sections, 7.2% (n = 250) contained 1 cell with IPV-virus DNA, which was restricted to the nucleus of neurons. In agreement with findings on herpes simplex virus infections, the viral DNA of BHV-1 is harbored in the local sensory ganglia. Virological and serological implications of the latent IPV infection are discussed.
将两头皮下接种从患有传染性脓疱性外阴阴道炎（IPV）的奶牛分离出的1型牛疱疹病毒（BHV-1，IBR/IPV）毒株。这些动物在感染潜伏期被处死，其特征为血清转化、无病毒脱落以及地塞米松治疗后病毒脱落复发。在这两头小牛的20个骶神经节中的9个中检测到了IPV病毒DNA。在切片中，7.2%（n = 250）含有1个带有IPV病毒DNA的细胞，该细胞局限于神经元细胞核。与单纯疱疹病毒感染的研究结果一致，BHV-1的病毒DNA存在于局部感觉神经节中。讨论了潜伏性IPV感染的病毒学和血清学意义。
