Panasenko O M, Azizova O A, Torkhovskaia T I, Dudaev V A
Biull Eksp Biol Med. 1984 May;97(5):558-61.
Structural properties of blood plasma lipoproteins (LP) from coronary heart disease (CHD) patients were examined. Substantial differences were found in the pattern of the heat-induced structural restitution of LP of all classes in health and disease. At the same time no such differences were discovered in lipids isolated from LP. In high density lipoproteins from the plasma of CHD patients, a decrease in the microenvironmental polarity was shown to take place at a depth of 8 A from the surface of LP. The data obtained indicate substantial changes in the structural organization of LP of all classes in CHD. It is assumed that these changes are consequent on the modification of apoproteins and/or protein-lipid interactions in LP.
对冠心病（CHD）患者血浆脂蛋白（LP）的结构特性进行了检测。结果发现，健康人和患病者所有类别LP的热诱导结构恢复模式存在显著差异。同时，从LP中分离出的脂质未发现此类差异。在冠心病患者血浆的高密度脂蛋白中，距LP表面8埃深度处的微环境极性降低。所得数据表明冠心病患者所有类别LP的结构组织发生了显著变化。据推测，这些变化是LP中载脂蛋白和/或蛋白质-脂质相互作用改变的结果。
