Dowlatshahi K, Mehta R G, Levin B, Cerny W L, Skinner D B, Moon R C
Cancer. 1984 Jul 15;54(2):308-11. doi: 10.1002/1097-0142(19840715)54:2<308::aid-cncr2820540221>3.0.co;2-4.
The concentration of cellular retinoic acid binding proteins (CRABP) was determined in the cytosol of normal esophageal tissue and in esophageal carcinomas. Unlike the reported results for human breast, colon, melanoma, or oropharynx cancers, the CRABP levels in esophageal cancers were either undetectable or contained levels of CRABP which were significantly lower than that of adjacent histologically disease-free tissue (P less than 0.005). Moreover, there was no difference between the normal mucosa of cancer or noncancer patients with regards to the CRABP concentration. The absence of CRABP in the cancer tissue was not dependent on the degree of differentiation. These results indicate that the CRABP disappears when the normal mucosa becomes malignant. If such a change is also demonstrated in known premalignant conditions of the esophagus, CRABP could serve as a diagnostic biochemical marker for early detection of this cancer.
测定了正常食管组织和食管癌细胞质中细胞视黄酸结合蛋白（CRABP）的浓度。与报道的人类乳腺癌、结肠癌、黑色素瘤或口咽癌的结果不同，食管癌中的CRABP水平要么无法检测到，要么其含量明显低于相邻组织学上无病变的组织（P<0.005）。此外，癌症患者和非癌症患者的正常黏膜在CRABP浓度方面没有差异。癌组织中CRABP的缺失不依赖于分化程度。这些结果表明，当正常黏膜发生恶变时，CRABP会消失。如果在已知的食管癌前病变中也出现这种变化，CRABP可作为早期检测该癌症的诊断生化标志物。
