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编码单纯疱疹病毒1型调节多肽Vmw 175的立即早期信使核糖核酸未被剪接。

The immediate-early mRNA that encodes the regulatory polypeptide Vmw 175 of herpes simplex virus type 1 is unspliced.

作者信息

Rixon F J, Campbell M E, Clements J B

出版信息

EMBO J. 1982;1(10):1273-7. doi: 10.1002/j.1460-2075.1982.tb00024.x.

DOI:10.1002/j.1460-2075.1982.tb00024.x
PMID:6327260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC553200/
Abstract

The structure and precise map location of the 4.1-kb herpes simplex virus type 1 (HSV-1) immediate-early mRNA (IE mRNA-3) that encodes a regulatory polypeptide, with an approximate mol. wt. of 175 000, has been determined. Nuclease S1 digestion procedures using labelled virus DNA probes have shown that IE mRNA-3 is unspliced and maps entirely within the TRs/IRs genome regions. DNA sequences at the 5' and 3' ends of IE mRNA-3 have been examined and regulatory signals involved in initiation of transcription and polyadenylation have been identified. No other mRNA is known to map within the region coding for IE mRNA-3.

摘要

编码一种分子量约为175000的调节多肽的4.1千碱基单纯疱疹病毒1型（HSV-1）立即早期信使核糖核酸（IE mRNA-3）的结构和精确图谱定位已被确定。使用标记病毒DNA探针的核酸酶S1消化程序表明，IE mRNA-3未被剪接，并且完全定位在TRs/IRs基因组区域内。已检查了IE mRNA-3 5'和3'末端的DNA序列，并鉴定了参与转录起始和聚腺苷酸化的调节信号。已知没有其他信使核糖核酸定位在编码IE mRNA-3的区域内。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/fb39ec4d293b/emboj00302-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/c37e2c89d972/emboj00302-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/48f578af4802/emboj00302-0124-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/f5c7c32cf533/emboj00302-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/ad177f3e7c47/emboj00302-0125-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/fb39ec4d293b/emboj00302-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/c37e2c89d972/emboj00302-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/48f578af4802/emboj00302-0124-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/f5c7c32cf533/emboj00302-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/ad177f3e7c47/emboj00302-0125-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1a/553200/fb39ec4d293b/emboj00302-0126-a.jpg

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The immediate-early mRNA that encodes the regulatory polypeptide Vmw 175 of herpes simplex virus type 1 is unspliced.编码单纯疱疹病毒1型调节多肽Vmw 175的立即早期信使核糖核酸未被剪接。
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本文引用的文献

1
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Nucleic Acids Res. 1980 Mar 11;8(5):957-77. doi: 10.1093/nar/8.5.957.
2
Localization of an origin of DNA replication within the TRS/IRS repeated region of the herpes simplex virus type 1 genome.单纯疱疹病毒1型基因组TRS/IRS重复区域内DNA复制起始位点的定位
EMBO J. 1982;1(7):863-7. doi: 10.1002/j.1460-2075.1982.tb01261.x.
3
Detailed structural analysis of two spliced HSV-1 immediate-early mRNAs.
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Nucleic Acids Res. 1984 Mar 12;12(5):2473-87. doi: 10.1093/nar/12.5.2473.
4
Functional analysis of a herpes simplex virus type 1 promoter: identification of far-upstream regulatory sequences.单纯疱疹病毒1型启动子的功能分析：远端上游调控序列的鉴定
Nucleic Acids Res. 1983 Apr 25;11(8):2347-65. doi: 10.1093/nar/11.8.2347.
5
Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.疱疹病毒产物对转录的反式激活：最大活性需要两种单纯疱疹病毒1型立即早期多肽。
EMBO J. 1984 Dec 20;3(13):3135-41. doi: 10.1002/j.1460-2075.1984.tb02270.x.
6
Sequences of herpes simplex virus type 1 that inhibit formation of stable TK+ transformants.抑制稳定的胸苷激酶阳性转化体形成的1型单纯疱疹病毒序列。
J Virol. 1987 Oct;61(10):2989-96. doi: 10.1128/JVI.61.10.2989-2996.1987.
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9
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J Virol. 1981 Aug;39(2):559-72. doi: 10.1128/JVI.39.2.559-572.1981.
10
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J Virol. 1981 May;38(2):483-96. doi: 10.1128/JVI.38.2.483-496.1981.