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1
The immediate-early enhancer element of herpes simplex virus type 1 can replace a regulatory region of the c-Ha-ras1 oncogene required for transformation.单纯疱疹病毒1型的立即早期增强子元件可替代c-Ha-ras1癌基因转化所需的调控区域。
J Virol. 1985 Jun;54(3):879-81. doi: 10.1128/JVI.54.3.879-881.1985.
2
A modular system for the assay of transcription regulatory signals: the sequence TAATGARAT is required for herpes simplex virus immediate early gene activation.一种用于检测转录调控信号的模块化系统：单纯疱疹病毒立即早期基因激活需要TAATGARAT序列。
Nucleic Acids Res. 1985 Nov 11;13(21):7847-63. doi: 10.1093/nar/13.21.7847.
3
Transfection with the isolated herpes simplex virus thymidine kinase genes. I. Minimal size of the active fragments from HSV-1 and HSV-2.用分离出的单纯疱疹病毒胸苷激酶基因进行转染。I. 来自HSV-1和HSV-2的活性片段的最小大小。
J Gen Virol. 1982 Oct;62 (Pt 2):191-206. doi: 10.1099/0022-1317-62-2-191.
4
DNA sequence of an immediate-early gene (IEmRNA-5) of herpes simplex virus type I.单纯疱疹病毒I型即刻早期基因（IEmRNA-5）的DNA序列
Nucleic Acids Res. 1982 Feb 11;10(3):979-91. doi: 10.1093/nar/10.3.979.
5
Nucleotide sequence of the herpes simplex virus type 2 (HSV-2) thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thymidine kinase gene.单纯疱疹病毒2型（HSV - 2）胸苷激酶基因的核苷酸序列、胸苷激酶多肽的预测氨基酸序列及其与HSV - 1胸苷激酶基因的比较。
Biochim Biophys Acta. 1983 Nov 17;741(2):158-70. doi: 10.1016/0167-4781(83)90056-8.
6
Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175.猿猴病毒40早期启动子-增强子在1型单纯疱疹病毒载体中的活性取决于其位置、感染的细胞类型以及Vmw175的存在。
J Virol. 1991 Dec;65(12):6900-12. doi: 10.1128/JVI.65.12.6900-6912.1991.
7
DNA sequences which regulate the expression of the pseudorabies virus major immediate early gene.调控伪狂犬病病毒主要立即早期基因表达的DNA序列。
Virology. 1987 Apr;157(2):307-16. doi: 10.1016/0042-6822(87)90273-x.
8
Expression of human immunodeficiency virus type 1 gag gene using genetically engineered herpes simplex virus type 1 recombinants.
Virus Genes. 1990 Dec;4(4):325-37. doi: 10.1007/BF00570027.
9
DNA amplification and neoplastic transformation mediated by a herpes simplex DNA fragment containing cell-related sequences.由包含细胞相关序列的单纯疱疹病毒DNA片段介导的DNA扩增和肿瘤转化
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1738-42. doi: 10.1073/pnas.83.6.1738.
10
Expression of recombinant genes containing herpes simplex virus delayed-early and immediate-early regulatory regions and trans activation by herpesvirus infection.含有单纯疱疹病毒延迟早期和即刻早期调控区的重组基因的表达以及疱疹病毒感染后的反式激活作用。
J Virol. 1984 Nov;52(2):522-31. doi: 10.1128/JVI.52.2.522-531.1984.

引用本文的文献

1
Harvey ras genes transform without mutant codons, apparently activated by truncation of a 5' exon (exon -1).哈维Ras基因在没有突变密码子的情况下发生转化，显然是由5'外显子（外显子-1）的截短激活的。
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2340-4. doi: 10.1073/pnas.83.8.2340.
2
rasH mutants deficient in GTP binding.缺乏GTP结合能力的rasH突变体。
Mol Cell Biol. 1986 Sep;6(9):3291-4. doi: 10.1128/mcb.6.9.3291-3294.1986.
3
Oncogene-induced transformation of a rat embryo fibroblast cell line is enhanced by tumor promoters.肿瘤启动子可增强癌基因诱导的大鼠胚胎成纤维细胞系的转化。
Mol Cell Biol. 1986 Jun;6(6):1943-50. doi: 10.1128/mcb.6.6.1943-1950.1986.
4
Mutants defective in herpes simplex virus type 2 ICP4: isolation and preliminary characterization.2型单纯疱疹病毒ICP4缺陷型突变体：分离与初步鉴定
J Virol. 1987 Apr;61(4):1092-7. doi: 10.1128/JVI.61.4.1092-1097.1987.
5
Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site.单纯疱疹病毒立即早期基因产物ICP4与其自身转录起始位点的结合。
J Virol. 1987 Mar;61(3):858-65. doi: 10.1128/JVI.61.3.858-865.1987.
6
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.在表达EJ人膀胱ras癌基因的NIH-3T3细胞中，激素刺激的腺苷酸环化酶活性降低。
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3703-7. doi: 10.1073/pnas.83.11.3703.
7
Analysis of DNA sequences which regulate the transcription of herpes simplex virus immediate early gene 3: DNA sequences required for enhancer-like activity and response to trans-activation by a virion polypeptide.单纯疱疹病毒立即早期基因3转录调控的DNA序列分析：增强子样活性及对病毒体多肽反式激活反应所需的DNA序列
Nucleic Acids Res. 1986 Jan 24;14(2):929-43. doi: 10.1093/nar/14.2.929.
8
DNA sequence of the herpes simplex virus type 1 gene whose product is responsible for transcriptional activation of immediate early promoters.单纯疱疹病毒1型基因的DNA序列，其产物负责立即早期启动子的转录激活。
Nucleic Acids Res. 1985 Nov 11;13(21):7865-79. doi: 10.1093/nar/13.21.7865.

本文引用的文献

1
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.一个点突变导致了T24人膀胱癌癌基因获得转化特性。
Nature. 1982 Nov 11;300(5888):149-52. doi: 10.1038/300149a0.
2
SEQ: a nucleotide sequence analysis and recombination system.SEQ：一种核苷酸序列分析与重组系统。
Nucleic Acids Res. 1982 Jan 11;10(1):279-94. doi: 10.1093/nar/10.1.279.
3
Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.人类肿瘤细胞系中的癌基因：从人膀胱癌细胞中克隆一个转化基因
Proc Natl Acad Sci U S A. 1982 May;79(9):2845-9. doi: 10.1073/pnas.79.9.2845.
4
Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene.T24人膀胱癌癌基因的核苷酸序列分析
Science. 1983 Jun 3;220(4601):1061-3. doi: 10.1126/science.6844927.
5
The immediate-early mRNA that encodes the regulatory polypeptide Vmw 175 of herpes simplex virus type 1 is unspliced.编码单纯疱疹病毒1型调节多肽Vmw 175的立即早期信使核糖核酸未被剪接。
EMBO J. 1982;1(10):1273-7. doi: 10.1002/j.1460-2075.1982.tb00024.x.
6
Transcriptional regulation of a herpes simplex virus immediate early gene is mediated through an enhancer-type sequence.单纯疱疹病毒立即早期基因的转录调控是通过一种增强子样序列介导的。
EMBO J. 1984 Feb;3(2):389-95. doi: 10.1002/j.1460-2075.1984.tb01817.x.
7
Replication origins and a sequence involved in coordinate induction of the immediate-early gene family are conserved in an intergenic region of herpes simplex virus.复制起点以及参与立即早期基因家族协同诱导的一个序列在单纯疱疹病毒的一个基因间区域中是保守的。
Nucleic Acids Res. 1984 Feb 24;12(4):2061-79. doi: 10.1093/nar/12.4.2061.
8
BK viral enhancer element and a human cellular homolog.BK病毒增强子元件和一种人类细胞同源物。
Science. 1983 Nov 18;222(4625):749-55. doi: 10.1126/science.6314501.
9
Repeat array in Epstein-Barr virus DNA is related to cell DNA sequences interspersed on human chromosomes.爱泼斯坦-巴尔病毒DNA中的重复序列与散布在人类染色体上的细胞DNA序列相关。
Proc Natl Acad Sci U S A. 1982 Oct;79(19):5916-20. doi: 10.1073/pnas.79.19.5916.
10
Functional analysis of a herpes simplex virus type 1 promoter: identification of far-upstream regulatory sequences.单纯疱疹病毒1型启动子的功能分析：远端上游调控序列的鉴定
Nucleic Acids Res. 1983 Apr 25;11(8):2347-65. doi: 10.1093/nar/11.8.2347.

单纯疱疹病毒1型的立即早期增强子元件可替代c-Ha-ras1癌基因转化所需的调控区域。

The immediate-early enhancer element of herpes simplex virus type 1 can replace a regulatory region of the c-Ha-ras1 oncogene required for transformation.

作者信息

Puga A, Gomez-Marquez J, Brayton P R, Cantin E M, Long L K, Barbacid M, Notkins A L

出版信息

J Virol. 1985 Jun;54(3):879-81. doi: 10.1128/JVI.54.3.879-881.1985.

DOI:10.1128/JVI.54.3.879-881.1985
PMID:2987541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254880/
Abstract

A 0.8-kilobase SacI DNA fragment in the distal 5'-noncoding region of the c-Ha-ras1 oncogene hybridized to high guanine X cytosine sites of herpes simplex virus type 1 (HSV-1) DNA restriction fragments. Nucleotide sequence comparisons localized one of these sites to the intergenic region of HSV between the immediate-early genes coding for IEmRNA-3 and IEmRNA-4/5 that has enhancer-type activity. We tested the possibility that the HSV-1 enhancer and the upstream c-Ha-ras1 SacI fragment were functionally related by assaying for the capacity of recombinant plasmids in which the HSV-1 enhancer replaced the oncogene 0.8-kilobase SacI fragment to transform NIH/3T3 cells. Deletion of the 0.8-kilobase SacI fragment abolished the biological activity of c-Ha-ras1, but its replacement by the HSV-1 enhancer fully restored it. These results confirm the enhancer properties of the HSV-1 immediate-early intergenic region and suggest that c-Ha-ras1 sequences contained within the 0.8-kilobase SacI fragment plays a role in the transcriptional activation of the oncogene.

摘要

c-Ha-ras1癌基因5'-非编码区远端的一个0.8千碱基的SacI DNA片段与单纯疱疹病毒1型（HSV-1）DNA限制片段的高鸟嘌呤X胞嘧啶位点杂交。核苷酸序列比较将其中一个位点定位到HSV编码IEmRNA-3和IEmRNA-4/5的立即早期基因之间的基因间区域，该区域具有增强子样活性。我们通过检测重组质粒（其中HSV-1增强子取代癌基因0.8千碱基的SacI片段）转化NIH/3T3细胞的能力，来测试HSV-1增强子与上游c-Ha-ras1 SacI片段在功能上是否相关。删除0.8千碱基的SacI片段消除了c-Ha-ras1的生物学活性，但其被HSV-1增强子取代后完全恢复了活性。这些结果证实了HSV-1立即早期基因间区域的增强子特性，并表明0.8千碱基SacI片段中包含的c-Ha-ras1序列在癌基因的转录激活中起作用。