豚鼠单纯疱疹病毒感染：一种用于研究单纯疱疹病毒潜伏和复发感染的动物模型。
Herpes simplex virus infection in guinea pigs: an animal model for studying latent and recurrent herpes simplex virus infection.
作者信息
Scriba M
出版信息
Infect Immun. 1975 Jul;12(1):162-5. doi: 10.1128/iai.12.1.162-165.1975.
Abstract
Footpad infection of guinea pigs with herpes simplex virus led to an acute local inflammatory reaction, followed by a persistent latent infection of lumbosacral dorsal root ganglia. Spontaneous reactivation of the latent virus occurred, leading to recurrent lesions at the site of the initial infection. Clinical observations and virological studies during the acute latent and recurrent infection are reported.
摘要
用单纯疱疹病毒感染豚鼠足垫会引发急性局部炎症反应，随后导致腰骶部背根神经节持续性潜伏感染。潜伏病毒会自发激活，导致初始感染部位反复出现病变。本文报道了急性潜伏感染和复发感染期间的临床观察和病毒学研究情况。
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