单纯疱疹病毒2型胸苷激酶对四种无环鸟苷类似物的磷酸化作用。
Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase.
作者信息
Larsson A, Tao P Z
出版信息
Antimicrob Agents Chemother. 1984 Apr;25(4):524-6. doi: 10.1128/AAC.25.4.524.
Abstract
Four acyclic guanosine analogs, the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine, 9-(4-hydroxybutyl)guanine, and acyclovir were compared in enzyme kinetic experiments, using purified herpes simplex virus type 2 thymidine kinase. All four analogs showed competitive patterns of inhibition in the phosphorylation of thymidine by the viral thymidine kinase, but different affinities and relative rates of phosphorylation were observed.
摘要
利用纯化的2型单纯疱疹病毒胸苷激酶，在酶动力学实验中比较了四种无环鸟苷类似物，即9-(3,4-二羟基丁基)鸟嘌呤的(R)和(S)对映体、9-(4-羟基丁基)鸟嘌呤和阿昔洛韦。所有四种类似物在病毒胸苷激酶使胸苷磷酸化的过程中均表现出竞争性抑制模式，但观察到了不同的亲和力和相对磷酸化速率。
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