• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

单纯疱疹病毒2型胸苷激酶对四种无环鸟苷类似物的磷酸化作用。

Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase.

作者信息

Larsson A, Tao P Z

出版信息

Antimicrob Agents Chemother. 1984 Apr;25(4):524-6. doi: 10.1128/AAC.25.4.524.

DOI:10.1128/AAC.25.4.524
PMID:6329085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185571/
Abstract

Four acyclic guanosine analogs, the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine, 9-(4-hydroxybutyl)guanine, and acyclovir were compared in enzyme kinetic experiments, using purified herpes simplex virus type 2 thymidine kinase. All four analogs showed competitive patterns of inhibition in the phosphorylation of thymidine by the viral thymidine kinase, but different affinities and relative rates of phosphorylation were observed.

摘要

利用纯化的2型单纯疱疹病毒胸苷激酶，在酶动力学实验中比较了四种无环鸟苷类似物，即9-(3,4-二羟基丁基)鸟嘌呤的(R)和(S)对映体、9-(4-羟基丁基)鸟嘌呤和阿昔洛韦。所有四种类似物在病毒胸苷激酶使胸苷磷酸化的过程中均表现出竞争性抑制模式，但观察到了不同的亲和力和相对磷酸化速率。

相似文献

1
Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase.单纯疱疹病毒2型胸苷激酶对四种无环鸟苷类似物的磷酸化作用。
Antimicrob Agents Chemother. 1984 Apr;25(4):524-6. doi: 10.1128/AAC.25.4.524.
2
Acyclic guanosine analogs as substrates for varicella-zoster virus thymidine kinase.无环鸟苷类似物作为水痘带状疱疹病毒胸苷激酶的底物
Antimicrob Agents Chemother. 1986 Jan;29(1):171-4. doi: 10.1128/AAC.29.1.171.
3
Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.2型单纯疱疹病毒的临床分离株，可诱导产生底物特异性改变的胸苷激酶。
Antimicrob Agents Chemother. 1987 Jul;31(7):1117-25. doi: 10.1128/AAC.31.7.1117.
4
Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.9-(4-羟丁基)鸟嘌呤以及9-(3,4-二羟丁基)鸟嘌呤的(R)和(S)对映体的抗疱疹作用和药代动力学特性。
Antimicrob Agents Chemother. 1985 May;27(5):753-9. doi: 10.1128/AAC.27.5.753.
5
Inhibition of herpes simplex virus-induced DNA polymerases and cellular DNA polymerase alpha by triphosphates of acyclic guanosine analogs.无环鸟苷类似物三磷酸盐对单纯疱疹病毒诱导的DNA聚合酶和细胞DNA聚合酶α的抑制作用。
Mol Pharmacol. 1986 Jun;29(6):614-21.
6
9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication.9-（3,4-二羟基丁基）鸟嘌呤，一种新型疱疹病毒增殖抑制剂。
Antimicrob Agents Chemother. 1983 May;23(5):664-70. doi: 10.1128/AAC.23.5.664.
7
Properties of a novel thymidine kinase induced by an acyclovir-resistant herpes simplex virus type 1 mutant.由耐阿昔洛韦的1型单纯疱疹病毒突变体诱导产生的一种新型胸苷激酶的特性
J Virol. 1982 May;42(2):649-58. doi: 10.1128/JVI.42.2.649-658.1982.
8
Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine.在细胞培养中对胸腺嘧啶核苷逆转核苷类似物抗疱疹活性的动力学分析。
Antimicrob Agents Chemother. 1983 Nov;24(5):819-22. doi: 10.1128/AAC.24.5.819.
9
Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir.一些与布昔洛韦相关的新型抗疱疹病毒鸟苷类似物的作用模式、毒性、药代动力学及疗效
Antimicrob Agents Chemother. 1986 Oct;30(4):598-605. doi: 10.1128/AAC.30.4.598.
10
Metabolism and mode of action of (R)-9-(3,4-dihydroxybutyl)guanine in herpes simplex virus-infected vero cells.（R）-9-（3,4-二羟基丁基）鸟嘌呤在单纯疱疹病毒感染的非洲绿猴肾细胞中的代谢及作用方式
J Biol Chem. 1986 Feb 15;261(5):2134-9.

引用本文的文献

1
Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro.格尔德霉素是热休克蛋白90的一种配体，可在体外抑制单纯疱疹病毒1型的复制。
Antimicrob Agents Chemother. 2004 Mar;48(3):867-72. doi: 10.1128/AAC.48.3.867-872.2004.
2
Acyclic guanosine analogs as inhibitors of human cytomegalovirus.无环鸟苷类似物作为人巨细胞病毒的抑制剂
Antimicrob Agents Chemother. 1987 Feb;31(2):317-20. doi: 10.1128/AAC.31.2.317.
3
Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir.一些与布昔洛韦相关的新型抗疱疹病毒鸟苷类似物的作用模式、毒性、药代动力学及疗效
Antimicrob Agents Chemother. 1986 Oct;30(4):598-605. doi: 10.1128/AAC.30.4.598.
4
Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.单纯疱疹病毒DNA聚合酶基因内赋予对（R）-9-（3,4-二羟基丁基）鸟嘌呤抗性的突变。
Antimicrob Agents Chemother. 1986 Sep;30(3):502-4. doi: 10.1128/AAC.30.3.502.
5
Acyclic guanosine analogs as substrates for varicella-zoster virus thymidine kinase.无环鸟苷类似物作为水痘带状疱疹病毒胸苷激酶的底物
Antimicrob Agents Chemother. 1986 Jan;29(1):171-4. doi: 10.1128/AAC.29.1.171.
6
Efficacy of the acyclic guanosine analog buciclovir [(R)-9-(3,4-dihydroxybutyl)guanine] in experimental genital herpes.无环鸟苷类似物布昔洛韦[（R）-9-（3,4-二羟基丁基）鸟嘌呤]在实验性生殖器疱疹中的疗效。
Antimicrob Agents Chemother. 1986 Feb;29(2):294-7. doi: 10.1128/AAC.29.2.294.
7
Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.9-(4-羟丁基)鸟嘌呤以及9-(3,4-二羟丁基)鸟嘌呤的(R)和(S)对映体的抗疱疹作用和药代动力学特性。
Antimicrob Agents Chemother. 1985 May;27(5):753-9. doi: 10.1128/AAC.27.5.753.

本文引用的文献

1
The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.具有两种或更多种底物或产物的酶催化反应动力学。I. 命名法和速率方程。
Biochim Biophys Acta. 1963 Jan 8;67:104-37. doi: 10.1016/0006-3002(63)91800-6.
2
Antiviral and antitumor activities of 5-substituted 2'-deoxyuridines.5-取代2'-脱氧尿苷的抗病毒和抗肿瘤活性
Methods Find Exp Clin Pharmacol. 1980 Oct;2(5):253-67.
3
Antiherpetic activity and mechanism of action of 9-(4-hydroxybutyl)guanine.9-(4-羟丁基)鸟嘌呤的抗疱疹活性及作用机制。
Antiviral Res. 1983 Aug;3(2):77-86. doi: 10.1016/0166-3542(83)90028-1.
4
9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication.9-（3,4-二羟基丁基）鸟嘌呤，一种新型疱疹病毒增殖抑制剂。
Antimicrob Agents Chemother. 1983 May;23(5):664-70. doi: 10.1128/AAC.23.5.664.
5
Properties of purified enzymes induced by pathogenic drug-resistant mutants of herpes simplex virus. Evidence for virus variants expressing normal DNA polymerase and altered thymidine kinase.单纯疱疹病毒致病性耐药突变体诱导产生的纯化酶的特性。表达正常DNA聚合酶和改变的胸苷激酶的病毒变体的证据。
J Biol Chem. 1983 Feb 10;258(3):2027-33.
6
A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2.一种新的核苷类似物，9-[[2-羟基-1-(羟甲基)乙氧基]甲基]鸟嘌呤，在体外对1型和2型单纯疱疹病毒具有高度活性。
Antimicrob Agents Chemother. 1982 Jul;22(1):55-61. doi: 10.1128/AAC.22.1.55.
7
Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities.无环核苷类似物的酶促磷酸化及其与抗疱疹活性的相关性。
Biochem Pharmacol. 1981 Nov 15;30(22):3071-7. doi: 10.1016/0006-2952(81)90495-0.
8
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.单纯疱疹病毒的胸苷激酶可使新型抗病毒化合物9-(2-羟乙氧甲基)鸟嘌呤发生磷酸化。
J Biol Chem. 1978 Dec 25;253(24):8721-7.
9
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.一种抗疱疹剂9-(2-羟乙氧甲基)鸟嘌呤的作用选择性
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5716-20. doi: 10.1073/pnas.74.12.5716.
10
Deoxythymidine kinase induced in HeLa TK- cells by herpes simplex virus type I and type II. II. Purification and characterization.单纯疱疹病毒I型和II型在HeLa TK-细胞中诱导产生的脱氧胸苷激酶。II. 纯化与特性鉴定
J Biol Chem. 1976 May 10;251(9):2605-10.