Wong L Y, Chan S H, Oon C J, Rauff A
Histochem J. 1984 Jun;16(6):687-92. doi: 10.1007/BF01003395.
A study of 10 hepatoma patients was carried out for the detection and localization of oestrogen, progesterone, testosterone, and their corresponding binding sites in liver tumour cells using immunoperoxidase and immunofluorescent techniques on histopathological sections and cultured monolayers. None of the hepatomas was positive for progesterone and its receptor; one was positive for oestrogen and its receptor; five were positive for testosterone and its receptor. Oestrogen, testosterone and their respective receptors localized predominantly to the cytoplasm of hepatoma cells. The results obtained in this investigation reveal an association between testosterone and human liver cancer which may be useful in the selection and monitoring of liver cancer patients to future hormonal therapy.
对10名肝癌患者进行了一项研究，采用免疫过氧化物酶和免疫荧光技术，在组织病理学切片和培养的单层细胞上检测和定位肝肿瘤细胞中的雌激素、孕激素、睾酮及其相应的结合位点。所有肝癌组织中孕激素及其受体均为阴性；1例雌激素及其受体呈阳性；5例睾酮及其受体呈阳性。雌激素、睾酮及其各自的受体主要定位于肝癌细胞的细胞质中。本研究结果揭示了睾酮与人类肝癌之间的关联，这可能有助于肝癌患者未来激素治疗的选择和监测。
