Kuwano H, Sonoda T, Hashimoto H, Enjoji M
Cancer. 1984 Sep 1;54(5):837-42. doi: 10.1002/1097-0142(19840901)54:5<837::aid-cncr2820540513>3.0.co;2-8.
A case of dedifferentiated hepatocellular carcinoma with osteoclast-like giant cells resembling those of giant cell tumor of bone is presented. The clinicopathologic findings are described, and the literature concerning this type tumor is reviewed. The tumor differed histologically from a pleomorphic variant of hepatocellular carcinoma in that there were numerous osteoclast-like giant cells with numerous, small, uniform, benign-appearing nuclei. To the knowledge of the authors, there has been only one report of this type of tumor arising in the liver. The tumor contained a separate area of a histologically conventional hepatocellular carcinoma, in addition to the above giant cell areas.
本文报告一例具有破骨细胞样巨细胞的去分化肝细胞癌，其破骨细胞样巨细胞类似于骨巨细胞瘤。描述了该病例的临床病理特征，并复习了有关此类肿瘤的文献。该肿瘤在组织学上与肝细胞癌的多形性变体不同，因为存在大量具有许多小的、均匀的、外观良性核的破骨细胞样巨细胞。据作者所知，仅有一篇关于肝脏发生此类肿瘤的报道。除上述巨细胞区域外，肿瘤还包含一个组织学上为传统肝细胞癌的单独区域。
