Yokota M, Takeda U, Odaki M, Sasaki H, Kawaoto H, Watanabe H, Ishiwatari N, Koeda T
Jpn J Antibiot. 1984 Aug;37(8):1529-31.
Miocamycin (MOM) is a derivative of midecamycin and is metabolized into 4 main metabolites of Mb1, Mb2, Mb6 and Mb12. In the previous studies, we estimated LD50 values of Mb6 in male and female mice after single oral administration. The LD50 values were 4,150 mg/kg in male mice and 4,000 mg/kg in female mice, respectively. In the present studies, we evaluated acute toxicity and estimated LD50 values of Mb6 in male and female rats after single oral administration. Observations were continued for 1 week after treatment. It is concluded that LD0 values of Mb6 in male and female rats, were estimated more than 5,000 mg/kg as Mb6 did not exhibit any manifest acute toxicity even at the maximum physically applicable dose of 5,000 mg/kg.
麦白霉素（MOM）是麦迪霉素的衍生物，可代谢为4种主要代谢产物Mb1、Mb2、Mb6和Mb12。在之前的研究中，我们估算了单次口服给药后雄性和雌性小鼠体内Mb6的半数致死量（LD50）值。雄性小鼠的LD50值为4150 mg/kg，雌性小鼠的LD50值为4000 mg/kg。在本研究中，我们评估了单次口服给药后雄性和雌性大鼠体内Mb6的急性毒性并估算了其LD50值。给药后观察持续1周。结论是，雄性和雌性大鼠体内Mb6的最小致死量（LD0）值估计超过5000 mg/kg，因为即使在最大实际可行剂量5000 mg/kg时，Mb6也未表现出任何明显的急性毒性。
