Yokota M, Takeda U, Odaki M, Sasaki H, Kawaoto H, Watanabe H, Ishiwatari N, Koeda T
Jpn J Antibiot. 1984 Aug;37(8):1491-3.
Acute toxicity studies on miocamycin (MOM), non-crystalline solid, and its metabolite Mb1 were performed in mice in the previous studies. In the present studies, we evaluated acute toxicity of Mb1 in male and female rats after single oral administration at the maximum physically applicable dose of 5,000 mg/kg. Observations were continued for 1 week after treatment. It is concluded that LD0 values of Mb1 were estimated more than 5,000 mg/kg.
在之前的研究中，对非结晶性固体米卡霉素（MOM）及其代谢物Mb1进行了小鼠急性毒性研究。在本研究中，我们评估了Mb1在雄性和雌性大鼠单次口服最大实际可用剂量5000 mg/kg后的急性毒性。处理后持续观察1周。结论是，Mb1的LD0值估计超过5000 mg/kg。
