新型大环内酯类抗生素醋酸麦迪霉素（美欧卡霉素）的毒理学研究。第四部分-11。美欧卡霉素代谢产物的毒性：Mb12对大鼠的急性毒性。
Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-11. Toxicity of metabolites of miocamycin: acute toxicity of Mb12 in rats.
作者信息
Yokota M, Takeda U, Odaki M, Sasaki H, Kawaoto H, Watanabe H, Ishiwatari N, Koeda T
出版信息
Jpn J Antibiot. 1984 Aug;37(8):1549-51.
Miocamycin (MOM) is a derivative of midecamycin and is metabolized into 4 main metabolites of Mb1, Mb2, Mb6 and Mb12. In the previous studies, LD50 values of Mb12 were 5,750 mg/kg in male mice and 4,950 mg/kg in female mice, respectively. The object of this study was to evaluate acute toxicity in male and female rats after single oral administration of Mb12. Observations were continued for 1 week after treatment. It is concluded that LD0 values of Mb12 were estimated more than 5,000 mg/kg.
米卡霉素（MOM）是麦迪霉素的衍生物，可代谢为4种主要代谢物Mb1、Mb2、Mb6和Mb12。在先前的研究中，Mb12对雄性小鼠的半数致死量（LD50）值分别为5750毫克/千克，对雌性小鼠为4950毫克/千克。本研究的目的是评估单次口服Mb12后对雄性和雌性大鼠的急性毒性。处理后持续观察1周。得出的结论是，Mb12的最大耐受量（LD0）值估计超过5000毫克/千克。
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