新型大环内酯类抗生素醋酸麦迪霉素（麦白霉素）的毒理学研究。第四部分 - 5. 麦白霉素代谢产物的毒性：Mb2对大鼠的急性毒性
Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-5. Toxicity of metabolites of miocamycin: acute toxicity of Mb2 in rats.
作者信息
Yokota M, Takeda U, Odaki M, Sasaki H, Kawaoto H, Watanabe H, Ishiwatari N, Koeda T
出版信息
Jpn J Antibiot. 1984 Aug;37(8):1510-2.
PMID:6334175
Abstract
Miocamycin (MOM) is a derivative of midecamycin and is metabolized into 4 main metabolites. At previous study, LD0 values of Mb1 were estimated more than 5,000 mg/kg in male and female rats. The object of this study was to evaluate acute toxicity in male and female rats after single oral administration of Mb2, a metabolite of MOM. It is concluded that LD0 values of Mb2 were estimated more than 5,000 mg/kg.
摘要
米欧卡霉素（MOM）是麦迪霉素的衍生物，可代谢为4种主要代谢产物。在之前的研究中，Mb1在雄性和雌性大鼠中的半数致死量（LD0）估计超过5000毫克/千克。本研究的目的是评估单次口服给予MOM的代谢产物Mb2后，雄性和雌性大鼠的急性毒性。结论是，Mb2的LD0值估计超过5000毫克/千克。
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