Yokota M, Takeda U, Odaki M, Sasaki H, Kawaoto H, Itoh T, Koeda T
Jpn J Antibiot. 1984 Aug;37(8):1507-9.
Miocamycin (MOM) is a derivative of midecamycin and is metabolized into 4 main metabolites. At previous study, LD0 values of Mb1 were estimated more than 5,000 mg/kg in male and female mice. The object of this study was to evaluate acute toxicity in male and female mice after single oral administration of Mb2, a metabolite of MOM, at a dose level of 5,000 mg/kg as the maximum physically applicable dose. It is concluded that LD0 values of Mb2 were estimated more than 5,000 mg/kg.
米卡霉素（MOM）是麦迪霉素的衍生物，可代谢为4种主要代谢物。在先前的研究中，Mb1对雄性和雌性小鼠的半数致死量（LD0）估计超过5000mg/kg。本研究的目的是评估在最大实际可行剂量5000mg/kg下，单次口服给予MOM的代谢物Mb2后，雄性和雌性小鼠的急性毒性。得出的结论是，Mb2的LD0值估计超过5000mg/kg。
