Moriguchi M, Takeda U, Hata T, Yamamoto A, Koeda T
Jpn J Antibiot. 1984 Aug;37(8):1572-95.
Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the effect of MOM on reproductive performance in rats and rabbits. MOM, non-crystalline solid, was suspended in 0.1% CMC solution immediately before use. In this study, reproductive performance was studied according to the following designs: Fertility test (Segment I) in Wistar rats Teratogenicity test (Segment II) in Wistar rats Peri- and post-natal tests (Segment III) in Wistar rats Behavioral test in rat newborns in Segments II and III Teratogenicity test (Segment II) in New Zealand white rabbits In conclusion, MOM, non-crystalline solid, might have no teratogenesis and little influence on dams and their fetuses and offsprings.
麦白霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种从生米链霉菌培养液中分离出的大环内酯类抗生素。本研究的目的是确定麦白霉素对大鼠和家兔生殖性能的影响。麦白霉素为非结晶性固体，在使用前立即悬浮于0.1%羧甲基纤维素（CMC）溶液中。在本研究中，根据以下设计研究生殖性能：Wistar大鼠的生育力试验（第一部分）、Wistar大鼠的致畸性试验（第二部分）、Wistar大鼠的围产期和产后试验（第三部分）、第二和第三部分中新生大鼠的行为试验、新西兰白兔的致畸性试验（第二部分）。总之，非结晶性固体麦白霉素可能无致畸作用，对母鼠及其胎儿和后代影响较小。
