新型大环内酯类抗生素醋酸麦迪霉素（美欧卡霉素）的毒理学研究。第二部分-2. 家兔亚急性毒性试验
Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part II-2. Subacute toxicity in rabbits.
作者信息
Yokota M, Takeda U, Odaki M, Sasaki H, Niizato T, Kawaoto H, Kumagai K, Suzuki H, Hayasaka H, Suzuki M
出版信息
Jpn J Antibiot. 1984 Jul;37(7):1333-54.
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to examine toxicological effects in male and female rabbits after repeated oral administration of MOM, non-crystalline solid, for 5 weeks at daily dosages of 400, 800, 1,600 and 3,200 mg/kg. In conclusion, the maximum non-toxic dosage level of MOM, non-crystalline solid, is presumed to be 400 mg/kg in male and female rabbits with p.o. administered once daily for 5 weeks.
米欧卡霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种从生米卡链霉菌培养液中分离出的大环内酯类抗生素。本研究的目的是检查雄性和雌性兔子在连续5周每天口服400、800、1600和3200 mg/kg剂量的非结晶固体米欧卡霉素后的毒理学效应。总之，对于雄性和雌性兔子，连续5周每天口服给药，非结晶固体米欧卡霉素的最大无毒剂量水平推测为400 mg/kg。
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