新型大环内酯类抗生素醋酸麦迪霉素（美欧卡霉素）的毒理学研究。第一部分 - 1. 小鼠急性毒性试验
Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part I-1. Acute toxicity in mice.
作者信息
Yokota M, Takeda U, Odaki M, Sasaki H, Kawaoto H, Itoh T, Koeda T
出版信息
Jpn J Antibiot. 1984 Jul;37(7):1313-6.
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the acute toxicity of MOM, non-crystalline solid, in male and female mice (Jcl-ICR, SPF, 5-week-old) after single i.p., and p.o. administration of this material at a dose level of 5,000 mg/kg as the maximum physically applicable dose. MOM, non-crystalline solid, exhibited no acute toxicity in the present study. LD0 values were estimated as more than 5,000 mg/kg in each route of administration.
米卡霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种从生米卡链霉菌培养液中分离出的大环内酯类抗生素。本研究的目的是确定非结晶固体米卡霉素在单次腹腔注射和口服给药后，对雄性和雌性小鼠（Jcl-ICR，无特定病原体，5周龄）的急性毒性，给药剂量为5000mg/kg，这是该物质实际可应用的最大剂量。在本研究中，非结晶固体米卡霉素未表现出急性毒性。每种给药途径的LD0值估计均超过5000mg/kg。
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