Yokota M, Takeda U, Odaki M, Sasaki H, Niizato T, Kawaoto H, Watanabe H, Ishiwatari N, Koeda T
Jpn J Antibiot. 1984 Jul;37(7):1321-32.
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the subacute toxicity in male and female rats (Wistar, SPF, 5-week-old) after repeated oral administration of MOM, non-crystalline solid, for 5 weeks at selected dosage levels of 1,000, 2,000 and 4,000 mg/kg/day. It is concluded that the maximum non-toxic dosage level of MOM, non-crystalline solid, was 1,000 mg/kg/day but without specific toxic effects with rats when it was orally administered once daily for 5 weeks.
麦白霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种从生米卡链霉菌培养液中分离出的大环内酯类抗生素。本研究的目的是确定非结晶性固体麦白霉素在选定剂量水平（1000、2000和4000mg/kg/天）下，对雄性和雌性大鼠（Wistar，SPF，5周龄）连续口服给药5周后的亚急性毒性。得出的结论是，非结晶性固体麦白霉素的最大无毒剂量水平为1000mg/kg/天，但当每天口服给药5周时，对大鼠无特定毒性作用。
