Yokota M, Takeda U, Odaki M, Sasaki H, Kawaoto H, Watanabe H, Ishiwatari N, Koeda T
Jpn J Antibiot. 1984 Jul;37(7):1317-20.
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The object of this study was to determine the acute toxicity in male and female rats (Wistar, 5-week-old) after single i.p., s.c. and p.o. administration of MOM, non-crystalline solid, at a dose level of 5,000 mg/kg as the maximum physically applicable dose. Observations were kept for 1 week after administration. In conclusion, no animal died during an observation period for 1 week so that the LD0 values were estimated to be more than 5,000 mg/kg in all routes of administration.
米欧卡霉素（MOM）是麦迪霉素的衍生物，麦迪霉素是一种从生米卡链霉菌培养液中分离得到的大环内酯类抗生素。本研究的目的是确定5周龄雄性和雌性Wistar大鼠单次腹腔注射、皮下注射和口服非结晶固体米欧卡霉素，剂量水平为5000mg/kg（最大实际可行剂量）后的急性毒性。给药后观察1周。总之，在1周的观察期内没有动物死亡，因此所有给药途径的LD0值估计均大于5000mg/kg。
