Harisdangkul V, Barnes T Y, Songcharoen S, Pennebaker J B
J Rheumatol. 1984 Oct;11(5):638-43.
The presence of low molecular weight (LMW) IgM was found in 45% of patients with systemic lupus erythematosus (SLE). Complete chart analysis of clinical and laboratory variables was done on 39 patients with negative LMW IgM (Group 1) and on 40 patients with positive LMW IgM (Group 2). There were statistically significant differences between the 2 groups related to age at onset, hemoglobin concentration, IgM levels, and levels of anti-dsDNA. There were 12 known deaths among the 40 patients in the positive group (30.0%) and only 4 known deaths among the 39 patients in the negative group (10.26%), p less than 0.1. There were no significant intergroup differences of race, sex, mucocutaneous manifestations, arthritis, positive ANA, positive serologic test for syphilis by rapid plasma reagent, Coombs' positive anemia, thrombocytopenia, serositis, incidence of renal and central nervous system involvement. Our study shows that LMW IgM occurred in about half of the patients with SLE. Patients with positive LMW IgM compared to those without it had greater mortality at an earlier age.
在45%的系统性红斑狼疮（SLE）患者中发现了低分子量（LMW）IgM。对39例LMW IgM阴性患者（第1组）和40例LMW IgM阳性患者（第2组）进行了临床和实验室变量的完整图表分析。两组在发病年龄、血红蛋白浓度、IgM水平和抗双链DNA水平方面存在统计学显著差异。阳性组40例患者中有12例已知死亡（30.0%），阴性组39例患者中只有4例已知死亡（10.26%），p小于0.1。在种族、性别、皮肤黏膜表现、关节炎、抗核抗体阳性、快速血浆反应素梅毒血清学试验阳性、库姆斯阳性贫血、血小板减少、浆膜炎、肾脏和中枢神经系统受累发生率方面，两组间无显著差异。我们的研究表明，约一半的SLE患者出现LMW IgM。与未出现LMW IgM的患者相比，出现LMW IgM的患者在较早年龄有更高的死亡率。
