疟疾和妊娠对孕期接种一剂和两剂吸附破伤风类毒素免疫反应的影响。
The influence of malaria and gestation on the immune response to one and two doses of adsorbed tetanus toxoid in pregnancy.
作者信息
Brabin B J, Nagel J, Hagenaars A M, Ruitenberg E, van Tilborgh A M
出版信息
Bull World Health Organ. 1984;62(6):919-30.
The effect of Plasmodium falciparum infection on the response to immunization with tetanus toxoid in pregnancy is of importance because malaria is more frequent and severe in pregnant women. This paper presents the results of a study in west Kenya of the antibody response to an adsorbed tetanus toxoid in primigravidae and multigravidae living under holoendemic conditions. There was no apparent influence of either P. falciparum infection or gestational age on the immune response to one and two doses of adsorbed toxoid. The antibody response in pregnant women with and without malaria was comparable to that in non-pregnant healthy adults. Previous studies of responses to primary immunization schedules in pregnant and non-pregnant women are reviewed.
恶性疟原虫感染对孕期破伤风类毒素免疫接种反应的影响至关重要，因为疟疾在孕妇中更为常见且病情更严重。本文介绍了在肯尼亚西部对处于高度流行环境下的初产妇和经产妇进行吸附破伤风类毒素抗体反应研究的结果。恶性疟原虫感染和孕周对一剂和两剂吸附类毒素的免疫反应均无明显影响。患疟疾和未患疟疾的孕妇的抗体反应与非孕健康成年人相当。本文还综述了以往关于孕妇和非孕妇对初次免疫接种方案反应的研究。
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