Roos E, van de Pavert I V
Clin Exp Metastasis. 1983 Apr-Jun;1(2):173-80. doi: 10.1007/BF00121496.
Previously we have described the infiltration of lymphosarcoma cells into hepatocyte cultures. The interaction between tumor cells and hepatocytes was comparable to that occurring during the formation of liver metastases. Presently we report that antigen-activated T lymphocytes, but not unstimulated T cells, infiltrate hepatocyte cultures in a manner comparable to the lymphosarcoma cells. Thus, liver-colonizing lymphoid tumor cells and activated non-transformed T cells apparently have common characteristics, that enable them to infiltrate between liver cells. A comparative study of activated and non-activated T cells may aid in elucidating these characteristics. In the intact liver activated lymphocytes did not infiltrate, probably because they were not arrested.
此前我们已描述过淋巴肉瘤细胞浸润肝细胞培养物的情况。肿瘤细胞与肝细胞之间的相互作用类似于肝转移形成过程中发生的情况。目前我们报告，抗原激活的T淋巴细胞，而非未受刺激的T细胞，以与淋巴肉瘤细胞类似的方式浸润肝细胞培养物。因此，定位于肝脏的淋巴样肿瘤细胞和活化的未转化T细胞显然具有共同特征，使它们能够在肝细胞之间浸润。对活化和未活化T细胞进行比较研究可能有助于阐明这些特征。在完整肝脏中，活化的淋巴细胞不会浸润，可能是因为它们没有停滞。
