复杂混合物生物分析的一般方法。
General approach to the biological analysis of complex mixtures.
作者信息
Thilly W G, Longwell J, Andon B M
出版信息
Environ Health Perspect. 1983 Feb;48:129-36. doi: 10.1289/ehp.8348129.
Abstract
The study of potential health effects of combustion effluents involves identifying the substances present and estimating the probable health hazards of each. Unfortunately, this second step cannot be done by using present techniques. Approximations of health hazards by bacterial and human cell assays are being used to set priorities for further biological studies and to suggest needs for modifications of combustion systems. The assumptions underlying this approximation are discussed, and several examples of combustion effluents are reviewed.
摘要
对燃烧废气潜在健康影响的研究包括识别其中存在的物质，并估计每种物质可能的健康危害。不幸的是，目前的技术无法完成第二步。通过细菌和人体细胞试验对健康危害进行近似评估，以确定进一步生物学研究的优先级，并提出对燃烧系统进行改进的需求。讨论了这种近似评估所依据的假设，并回顾了一些燃烧废气的例子。
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本文引用的文献
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J Natl Cancer Inst. 1979 Aug;63(2):309-12.
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Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium.鼠伤寒沙门氏菌中正向和反向突变试验的相对敏感性。
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4465-9. doi: 10.1073/pnas.75.9.4465.
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Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker.利用对8-氮杂鸟嘌呤的抗性作为遗传标记，在鼠伤寒沙门氏菌中进行定量正向突变试验。
Proc Natl Acad Sci U S A. 1978 Jan;75(1):410-4. doi: 10.1073/pnas.75.1.410.
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