鼠伤寒沙门氏菌中正向和反向突变试验的相对敏感性。
Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium.
作者信息
Skopek T R, Liber H L, Kaden D A, Thilly W G
出版信息
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4465-9. doi: 10.1073/pnas.75.9.4465.
Abstract
Forward mutation to 8-azaguanine resistance and reverse mutation to histidine prototrophy were measured in Salmonella typhimurium after treatment with 16 mutagens of both base-substitution and frameshift classes. The two approaches were found to be equisensitive for all 16 mutagens--i.e., induction of significant mutation occurred at similar concentrations in the forward mutation assay and in the most sensitive of the five Ames tester strains.
摘要
在用碱基置换和移码两类的16种诱变剂处理鼠伤寒沙门氏菌后，测定了对8-氮杂鸟嘌呤抗性的正向突变和对组氨酸原养型的回复突变。结果发现，对于所有16种诱变剂，这两种方法的敏感性相同——也就是说，在正向突变试验和五个艾姆斯试验菌株中最敏感的菌株中，在相似浓度下诱导出了显著的突变。
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