Buck R L, Alcantara A K, Uylangco C V, Cross J H
Am J Trop Med Hyg. 1983 Mar;32(2):212-6. doi: 10.4269/ajtmh.1983.32.212.
Results are presented from the 1,000 slide-confirmed malaria cases seen during the period August 1979-September 1981 at San Lazaro Hospital, in Manila, Philippines; 56% were caused by Plasmodium falciparum, 38% by P. vivax, 6% were mixed infections, and 0.1% by P. malariae. The overall case fatality rate was 1%, all due to P. falciparum. Cerebral involvement occurred in 7% and the case fatality rate was 20% compared to a case fatality rate of 0.2% among P. falciparum cases without cerebral involvement. In vivo chloroquine-resistant P. falciparum was seen in 4% of the cases, but of those treated in 1981, 9% of the cases showed resistance. The distribution of chloroquine-resistant cases by province in the Philippines is shown, with resistance being reported for the first time from Isabela, Bulacan, Zambales, Rizal and Bataan provinces. Diagnostic, clinical, and epidemiologic aspects of the cases are discussed, as well as the trend in malaria cases over the last 20 years.
本文呈现了1979年8月至1981年9月期间在菲律宾马尼拉市圣拉萨罗医院确诊的1000例疟疾病例的相关结果；其中56%由恶性疟原虫引起，38%由间日疟原虫引起，6%为混合感染，0.1%由三日疟原虫引起。总体病死率为1%，均由恶性疟原虫所致。7%的病例出现脑部受累，其病死率为20%，而无脑部受累的恶性疟病例病死率为0.2%。4%的病例中发现了体内氯喹耐药的恶性疟原虫，但在1981年接受治疗的病例中，9%表现出耐药性。文中展示了菲律宾各省氯喹耐药病例的分布情况，伊莎贝拉、布拉干、三描礼士、黎刹和巴丹等省首次报告出现耐药情况。本文还讨论了这些病例的诊断、临床和流行病学方面，以及过去20年疟疾病例的趋势。
