Morris L R, McGee J A, Kitabchi A E
Ann Intern Med. 1981 Apr;94(4 pt 1):469-71. doi: 10.7326/0003-4819-94-4-469.
To determine whether semiquantitative glucose measurements of spot urine specimens accurately reflect prevailing plasma glucose levels, we compared reported levels from 400 second-voided urines to simultaneous plasma determinations from 246 adult diabetics. Quantitative urine levels and plasma glucose levels correlated. However, when semiquantitative urinary determinations were compared to plasma glucose stratified into 0 to 149, 150 to 199, and greater than 200 mg/dL, 75% of the urine samples associated with plasma levels from 150 to 199 mg/dL were negative by Diastix, and 16.5% of samples negative by Diastix were in the 200+ mg/dL plasma range. Only 9% of samples from 0 to 149 mg/dL showed any positive Diastix readings. Because of the low sensitivity of semiquantitative methods, we fell that, except for detection of marked hyperglycemia, spot urine glucose determinations are inadequate as the sole means of clinical assessment for management of diabetic patients. Home glucose monitoring may be a better alternative for follow-up of these patients.
为了确定即时尿标本的半定量葡萄糖测量是否能准确反映当时的血浆葡萄糖水平，我们将400份第二次排尿的尿液报告水平与246名成年糖尿病患者同时进行的血浆检测结果进行了比较。尿葡萄糖定量水平与血浆葡萄糖水平相关。然而，当将半定量尿液检测结果与分为0至149、150至199以及大于200mg/dL的血浆葡萄糖水平进行比较时，与150至199mg/dL血浆水平相关的尿样中有75%的尿糖试纸检测为阴性，而尿糖试纸检测为阴性的样本中有16.5%的血浆葡萄糖水平在200mg/dL以上。0至149mg/dL的样本中只有9%的尿糖试纸检测呈阳性。由于半定量方法的敏感性较低，我们认为，除了检测明显的高血糖外，即时尿葡萄糖检测作为糖尿病患者临床评估管理的唯一手段是不够的。家庭血糖监测可能是对这些患者进行随访的更好选择。
