Allison R C, Parker J C, Duncan C E, Taylor A E
J Appl Physiol Respir Environ Exerc Physiol. 1983 Apr;54(4):943-9. doi: 10.1152/jappl.1983.54.4.943.
To determine the accuracy of thermal-dye indicator-dilution measurements of lung water during perfusion abnormalities, we embolized air into the lungs of 10 dogs anesthetized with pentobarbital and mechanically ventilated. A control period was followed by a period of air injection (10 ml) and subsequent air infusion (E1), a second period of air injection and infusion (E2), and a recovery period. Thermal and dye-dilution curves were obtained during each period, and cardiac output (CO), total thermal volume, intravascular volume, and extravascular thermal volume (ETV) were calculated. Pulmonary arterial pressure (Ppa) increased from 16 +/- 2 cmH2O during control to 29 +/- 3 cmH2O during E1 and to 40 +/- 3 cmH2O during E2 and decreased to 21 +/- 2 cmH2O during recovery. CO did not change, and pulmonary vascular resistance changed in a pattern similar to Ppa. ETV fell from 113 +/- 8 ml during control to 59 +/- 11 ml during E1 and to 29 +/- 9 ml during E2 and rose to 136 +/- 23 ml during recovery. There was no increase in extravascular lung water or mass determined gravimetrically at the end of the experiments. We conclude that the thermal-dye technique will underestimate lung water in nonedematous lungs if emboli prevent complete diffusion of the thermal indicator.
为了确定在灌注异常期间热染料指示剂稀释法测量肺水的准确性，我们将空气栓塞入10只戊巴比妥麻醉并机械通气的犬肺中。在一段对照期后，进行一段空气注入（10毫升）及随后的空气输注期（E1）、第二段空气注入及输注期（E2），以及一段恢复期。在每个时期获取热稀释曲线和染料稀释曲线，并计算心输出量（CO）、总热容积、血管内容积和血管外热容积（ETV）。肺动脉压（Ppa）在对照期为16±2厘米水柱，在E1期升至29±3厘米水柱，在E2期升至40±3厘米水柱，在恢复期降至21±2厘米水柱。CO未改变，肺血管阻力的变化模式与Ppa相似。ETV在对照期为113±8毫升，在E1期降至59±11毫升，在E2期降至29±9毫升，在恢复期升至136±23毫升。实验结束时，通过重量法测定的血管外肺水或肺质量没有增加。我们得出结论，如果栓子阻止热指示剂完全扩散，热染料技术会低估非水肿肺中的肺水。
