Peters B H, Fraim C J, Masel B E
Am J Med. 1983 Jun 14;74(6A):36-42. doi: 10.1016/0002-9343(83)90526-0.
Two-hundred-sixty-nine otherwise healthy persons experiencing periodic, moderately severe headache of a type that had previously responded to nonprescription medications completed this randomized, parallel, double-blind study. The three demographically similar subgroups took either 1,000 mg acetaminophen, 650 mg aspirin, or an identical placebo, for headache. Headache intensity and relief scores over the following six hours were obtained and assessed by sums of pain intensity difference and values of pain relief scores analyses. Responses for the group, and for the subgroup with tension headaches (107 persons) showed no differences between the effects of the active medications. The effects of each medication were strongly superior to placebo. There were no differences in side effects among the three treatment modalities. In persons experiencing tension-vascular headaches (162), only aspirin, at two hours, was superior to placebo, but direct comparison with acetaminophen suggested no real difference. Acetaminophen (1,000 mg) and aspirin (650 mg) are clinically similar in treating the headaches for which they are commonly taken. Recommendations for their use in treating headache should be based on individual patient suitability and on cost factors.
269名既往有过周期性中度严重头痛且之前服用非处方药有效的健康受试者完成了这项随机、平行、双盲研究。三个在人口统计学上相似的亚组分别服用1000毫克对乙酰氨基酚、650毫克阿司匹林或相同的安慰剂来缓解头痛。在接下来的六个小时内获取头痛强度和缓解评分，并通过疼痛强度差值总和和疼痛缓解评分分析值进行评估。该组以及紧张性头痛亚组（107人）的反应显示，活性药物的效果之间没有差异。每种药物的效果都明显优于安慰剂。三种治疗方式的副作用没有差异。在患有紧张性血管性头痛的受试者（162人）中，仅在两小时时阿司匹林优于安慰剂，但与对乙酰氨基酚的直接比较表明没有实际差异。对乙酰氨基酚（1000毫克）和阿司匹林（650毫克）在治疗常见头痛方面临床效果相似。关于它们用于治疗头痛的建议应基于个体患者的适用性和成本因素。
