Kawada T, Tohyama C, Suzuki S
Department of Public Health, Gunma University School of Medicine, Japan.
Int Arch Occup Environ Health. 1990;62(1):95-100. doi: 10.1007/BF00397855.
Urinary cadmium (Cd), N-acetyl-beta-D-glucosaminidase (NAG), metallothionein (MT), beta 2-microglobulin (BMG), and blood cadmium were determined in 79 workers who had been employed at a Cd pigment factory in Japan. The workers who had been dealing with Cd pigment manufacturing processes were estimated to be exposed to cadmium pigment dust at a maximum concentration of 3.0 micrograms/m3/8 h for about 20 years. The urinary Cd level ranged from 0.2 to 9.7 micrograms/g creatinine with a geometric mean of 1.02 micrograms/g creatinine. Pearson's correlation coefficients between logarithm of urinary Cd and that of NAG, MT, and BMG in urine were 0.45, 0.62, and 0.05, respectively. The correlation coefficients between blood Cd and urinary NAG, MT, and BMG were 0.21, 0.40, and -0.074, respectively. When partial correlation coefficients were calculated to exclude the contribution of age factor, urinary Cd turned out to be significantly correlated with urinary MT (r = 0.55) and NAG (r = 0.52). The present results indicate that urinary Cd is more closely associated with urinary MT and NAG than with BMG, and suggest that MT and NAG could be good indicators of Cd absorption in a Cd-exposed population whose mean urinary Cd level is relatively low, or less than 10 micrograms/g creatinine.
对79名曾在日本一家镉颜料工厂工作的工人测定了尿镉（Cd）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、金属硫蛋白（MT）、β2-微球蛋白（BMG）和血镉。据估计，从事镉颜料制造工艺的工人接触镉颜料粉尘的最大浓度为3.0微克/立方米/8小时，持续约20年。尿镉水平在0.2至9.7微克/克肌酐之间，几何平均值为1.02微克/克肌酐。尿镉对数与尿中NAG、MT和BMG对数之间的Pearson相关系数分别为0.45、0.62和0.05。血镉与尿NAG、MT和BMG之间的相关系数分别为0.21、0.40和-0.074。当计算偏相关系数以排除年龄因素的影响时，尿镉与尿MT（r = 0.55）和NAG（r = 0.52）显著相关。目前的结果表明，尿镉与尿MT和NAG的相关性比与BMG的相关性更强，提示在平均尿镉水平相对较低（即低于10微克/克肌酐）的镉暴露人群中，MT和NAG可能是镉吸收的良好指标。
