Roels H, Lauwerys R, Buchet J P, Bernard A, Garvey J S, Linton H J
Int Arch Occup Environ Health. 1983;52(2):159-66. doi: 10.1007/BF00405419.
Cadmium in blood (Cd-B) and in urine (Cd-U) and metallothionein (Mt-U) and beta 2-microglobulin in urine (beta 2m-U) were measured in 94 male Cd workers. The results were examined according to the workers' current exposure to cadmium (group C, n = 73, workers currently exposed to Cd; group R, n = 21, Cd workers removed from exposure or retired) and according to their renal status (group N, n = 66, normal beta 2m-U; group I, n = 28, beta 2m-U greater than 200 micrograms/g creatinine). The interrelationships between Mt-U, Cd-U, Cd-B and years of cadmium exposure were examined in the various subgroups. The study of the correlations between these variables demonstrates that Mt-U is directly correlated with Cd-U but not with Cd-B or years of Cd exposure. The association between Cd-U and Mt-U is independent of the status of renal function and the intensity of current exposure to cadmium. Under moderate chronic exposure to cadmium, the fraction of Cd-U which is directly influenced by recent exposure (Cd-B) is small in comparison with that influenced by the cadmium body burden.
对94名男性镉作业工人测定了血镉（Cd-B）、尿镉（Cd-U）、尿金属硫蛋白（Mt-U）和尿β2-微球蛋白（β2m-U）。根据工人当前的镉暴露情况（C组，n = 73，当前暴露于镉的工人；R组，n = 21，已脱离镉暴露或退休的镉作业工人）以及他们的肾脏状况（N组，n = 66，β2m-U正常；I组，n = 28，β2m-U大于200微克/克肌酐）对结果进行了分析。在各个亚组中研究了Mt-U、Cd-U、Cd-B与镉暴露年限之间的相互关系。对这些变量之间相关性的研究表明，Mt-U与Cd-U直接相关，但与Cd-B或镉暴露年限无关。Cd-U与Mt-U之间的关联独立于肾功能状态和当前镉暴露强度。在中度慢性镉暴露情况下，与受镉体内负荷影响的部分相比，近期暴露（Cd-B）直接影响的Cd-U部分较小。
