Recknagel R O
Life Sci. 1983 Aug 1;33(5):401-8. doi: 10.1016/0024-3205(83)90787-7.
An unknown chain of causality links the early events of CCl4 metabolism to emergence of the classical spectrum of pathological changes elicited by this hepatotoxin. Recent developments suggest that an early disturbance in hepatocellular Ca2+ homeostasis may be involved. The possibility that generation of toxic products of lipid peroxidation may act as toxicological "second messengers" linking events near cytochrome P-450 to distant parts of the cell seems unlikely. This mini-review attempts to highlight major recent developments underlying the current situation.
四氯化碳代谢的早期事件与这种肝毒素引发的经典病理变化谱之间存在着未知的因果关系链。最近的研究进展表明，肝细胞钙稳态的早期紊乱可能与之有关。脂质过氧化毒性产物的产生可能作为毒理学“第二信使”，将细胞色素P-450附近的事件与细胞的远处部分联系起来，这种可能性似乎不大。这篇综述试图突出当前形势背后的主要最新进展。
