Mirchamsy H
Rev Infect Dis. 1983 May-Jun;5(3):491-4. doi: 10.1093/clinids/5.3.491.
Mass immunization with live measles vaccine has been carried out in rural Iran since 1968. Two strains have been used: primary baby calf kidney cell-adapted Sugiyama strain and human diploid cell-adapted AIK strain. More than 94% of the susceptible children experimentally vaccinated with either of the two vaccines have shown seroconversion. Mass immunization in rural regions has covered about 80% of susceptible children. It is now recommended that the live vaccine be administered twice: the first dose at six to nine months and the second at 12-15 months of age. In all of 100 cases of subacute sclerosing panencephalitis (SSPE) observed in the Tehran region between 1977 and 1982, the patient had a history of measles infection in childhood; there was no indication that SSPE developed after vaccination. Most of the patients with SSPE have had a high titer of antibody to measles virus in serum and cerebrospinal fluid, and antibody has commonly been demonstrated in saliva as well.
自1968年以来，伊朗农村地区开展了麻疹活疫苗大规模免疫接种。使用了两种毒株：原代犊牛肾细胞适应的杉山株和人二倍体细胞适应的AIK株。用这两种疫苗之一进行实验性接种的易感儿童中，超过94%出现了血清转化。农村地区的大规模免疫接种覆盖了约80%的易感儿童。现在建议活疫苗接种两次：第一剂在6至9个月龄时接种，第二剂在12至15个月龄时接种。在1977年至1982年期间在德黑兰地区观察到的100例亚急性硬化性全脑炎（SSPE）病例中，所有患者童年都有麻疹感染史；没有迹象表明SSPE是在接种疫苗后发生的。大多数SSPE患者血清和脑脊液中对麻疹病毒的抗体滴度较高，唾液中也通常能检测到抗体。
