Eng R, Chmel H, Corrado M, Smith S M
Infection. 1983 May-Jun;11(3):132-6. doi: 10.1007/BF01641291.
The detection of cryptococcal polysaccharides in the serum is diagnostic of cryptococcosis in the absence of rheumatoid factor. The significance of the continued detection of this antigen in the serum during antifungal therapy is not known. Prolonged antigenemia might indicate ongoing active infection, delayed clearance of the polysaccharides from the blood, or continued release of the polysaccharide antigens from a reservoir of nonviable organisms. In seven cases the cryptococcosis with prolonged and high levels of cryptococcal polysaccharide antigenemia, the courses of antigenemia were determined. During the convalescent phase, the T 1/2's were approximately 48 hours for the antigen clearance in all the cases studied. The polysaccharide antigens recovered from the serum of one patient had molecular weights of greater than 200,000 daltons. In rabbits, a single intravenous injection of cryptococcal capsular polysaccharides showed a similarly slow clearance of the antigen with a T 1/2 of approximately 24 to 48 hours. These data suggest that adequately treated cases of cryptococcosis may have a predictable rate of antigen clearance from the serum during convalescence.
在没有类风湿因子的情况下，血清中隐球菌多糖的检测可诊断隐球菌病。抗真菌治疗期间血清中持续检测到该抗原的意义尚不清楚。长期抗原血症可能表明存在持续的活动性感染、多糖从血液中的清除延迟或多糖抗原从非存活生物体库中持续释放。在7例隐球菌病伴有长期高水平隐球菌多糖抗原血症的病例中，确定了抗原血症的病程。在恢复期，所有研究病例中抗原清除的半衰期约为48小时。从一名患者血清中回收的多糖抗原分子量大于200,000道尔顿。在兔子中，单次静脉注射隐球菌荚膜多糖显示抗原清除同样缓慢，半衰期约为24至48小时。这些数据表明，经过充分治疗的隐球菌病病例在恢复期血清中抗原清除率可能是可预测的。
