Lam S, Tan F, Chan H, Chan-Yeung M
J Allergy Clin Immunol. 1983 Aug;72(2):134-9. doi: 10.1016/0091-6749(83)90520-1.
We studied the relationship between specific IgE antibodies, nonspecific bronchial reactivity to methacholine, and the type of asthmatic reaction in patients with red cedar asthma. The level of circulating specific IgE antibodies (expressed as RAST ratios) was not related to the type of asthmatic reaction, the degree of nonspecific bronchial hyperreactivity [expressed by the provocative concentration of methacholine producing a 20% decrease in the forced expiratory volume in 1 sec (PC20)] or the index of reactivity to plicatic acid. On the other hand, methacholine PC20 was found to correlate with the index of reactivity to plicatic acid in the late asthmatic reaction (LAR) and both the immediate and late components of the dual asthmatic reaction (DAR). Development of the LAR is associated with increase in nonspecific bronchial hyperreactivity. Repeated inhalation challenge with plicatic acid in eight patients with LAR resulted in DAR in all. The results suggest that the mechanism responsible for the LAR is associated with an increase in nonspecific bronchial reactivity; furthermore, the immediate component of DAR could also be related to heightened bronchial hyperreactivity.
我们研究了红雪松哮喘患者中特异性IgE抗体、对乙酰甲胆碱的非特异性支气管反应性与哮喘反应类型之间的关系。循环特异性IgE抗体水平（以放射性过敏原吸附试验比值表示）与哮喘反应类型、非特异性支气管高反应性程度[以引起第1秒用力呼气量降低20%的乙酰甲胆碱激发浓度（PC20）表示]或对裂褶菌酸的反应性指数均无关。另一方面，发现乙酰甲胆碱PC20与迟发性哮喘反应（LAR）中对裂褶菌酸的反应性指数以及双相哮喘反应（DAR）的速发和迟发成分均相关。LAR的发生与非特异性支气管高反应性增加有关。对8例LAR患者反复进行裂褶菌酸吸入激发试验，均导致了DAR。结果表明，LAR的发病机制与非特异性支气管反应性增加有关；此外，DAR的速发成分也可能与支气管高反应性增强有关。
