Schiffrin A, Desrosiers M, Moffatt M, Belmonte M M
J Pediatr. 1983 Oct;103(4):522-7. doi: 10.1016/s0022-3476(83)80576-9.
Nineteen insulin-dependent diabetic adolescents who had poor control on twice daily injections and home glucose monitoring participated in a study assessing the feasibility of improved control. Using a randomized crossover protocol, we examined the relative efficacy of continuous subcutaneous insulin infusion and of intensive conventional therapy with three or four daily injections of insulin. Both therapies were regulated with home glucose monitoring. A marked improvement in control with both therapies was observed when mean blood glucose and glycosylated hemoglobin A1 were compared with conventional therapy. However, pump therapy resulted in significantly lower HbA1 than intensive therapy (P less than 0.05), despite a significantly lower total insulin dose (P less than 0.01). We conclude that in adolescents with type I diabetes, continuous subcutaneous insulin infusion is more effective in achieving improvement of diabetes control than is intensive conventional therapy in the outpatient setting.
19名每日两次注射胰岛素及家庭血糖监测但血糖控制不佳的胰岛素依赖型糖尿病青少年参与了一项评估改善控制可行性的研究。采用随机交叉方案，我们研究了持续皮下胰岛素输注与每日三次或四次注射胰岛素的强化常规治疗的相对疗效。两种治疗均通过家庭血糖监测进行调整。当将平均血糖和糖化血红蛋白A1与常规治疗进行比较时，观察到两种治疗的控制情况均有显著改善。然而，尽管总胰岛素剂量显著降低（P<0.01），泵治疗导致的糖化血红蛋白A1仍显著低于强化治疗（P<0.05）。我们得出结论，在1型糖尿病青少年中，在门诊环境下，持续皮下胰岛素输注在实现糖尿病控制改善方面比强化常规治疗更有效。
